Bisphosphonate guidelines
نویسندگان
چکیده
منابع مشابه
Singapore Cancer Network (SCAN) Guidelines for Bisphosphonate Use in the Adjuvant Breast Cancer Setting.
INTRODUCTION The SCAN breast cancer workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines regarding the optimal time-point for initiation of bisphosphonates when using adjuvant aromatase inhibitors (AIs) and provide a consensus for their role in modifying clinical breast cancer outcomes. MATERIALS AND METHODS The workgroup utilised a modified ADAPTE process t...
متن کاملBisphosphonate-associated osteonecrosis of the jaw: a literature review and clinical practice guidelines.
BACKGROUND Osteonecrosis of the jaw has recently been reported as a possible adverse drug effect from bisphosphonate therapy. Reports are coming from all over the world. Norvartis, a pharmaceutical manufacturer of two implicated drug products, has notified dentists in the United States and made recommendations for dental management of cases. MECHANISM OF ACTION The exact mechanism of bisphosp...
متن کاملBisphosphonate-associated adverse events.
The adverse events of the nitrogen-containing bisphosphonates are reviewed. Oral bisphosphonates (alendronate, risedronate and ibandronate), mainly used for the treatment of osteoporosis, have been associated with adverse events from the upper gastrointestinal tract, acute phase response, hypocalcaemia and secondary hyperparathyroidism, musculoskeletal pain, osteonecrosis of the jaw and ocular ...
متن کاملBisphosphonate mechanism of action.
The nitrogen-containing bisphosphonates (N-BPs), alendronate and risedronate, are the only pharmacologic agents shown to prevent spine and nonvertebral fractures associated with postmenopausal and glucocorticoid-induced osteoporosis. At the tissue level, this is achieved through osteoclast inhibition, which leads to reduced bone turnover, increased bone mass, and improved mineralization. The mo...
متن کاملBisphosphonate-associated mandibular osteonecrosis.
A 66-year-old man with multiple myeloma treated with zoledronic acid, melphalan, and prednisone after a tooth extraction developed severe osteonecrosis of the mandible that was nonresponsive to antibiotic therapy. A CT scan showed innumerable fragmented sequestra in the mandible and some adjacent soft tissue fullness around the mandible. The association between the use of bisphosphonates and os...
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ژورنال
عنوان ژورنال: British Dental Journal
سال: 2006
ISSN: 0007-0610,1476-5373
DOI: 10.1038/sj.bdj.4813573